ABSTRACT
BACKGROUND: Chronic kidney disease (CKD) is a growing public health concern, and available treatments are insufficient in limiting disease progression. New strategies, including regenerative cell-based therapies, have emerged as therapeutic alternatives. Results from several groups, including our own, have reported evidence of a supportive role for mesenchymal stromal cells (MSCs) in functional recovery and prevention of tissue damage in murine models of CKD. Prompted by these data, an open pilot study was conducted to assess the safety and efficacy of a single injection of autologous adipose tissue-derived MSCs (AT-MSCs) for treatment of CKD. METHODS: AT-MSCs were infused intravenously into six CKD patients at a dose of 1 million cells/kg. Patients were stabilized and followed for one year prior to MSC infusion and one year following infusion. RESULTS: No patients presented with adverse effects. Statistically significant improvement in urinary protein excretion was observed in AT-MSCs transplanted patients, from a median of 0.75 g/day (range, 0.15–9.57) at baseline to 0.54 g/day (range, 0.01v2.66) at month 12 (P = 0.046). The glomerular filtration rate was not significantly decreased post-infusion of AT-MSCs. CONCLUSION: Findings from this pilot study demonstrate that intravenous infusion of autologous expanded AT-MSCs into CKD patients was not associated with adverse effects and could benefit patients already undergoing standard medical treatment.
Subject(s)
Humans , Disease Progression , Glomerular Filtration Rate , Infusions, Intravenous , Mesenchymal Stem Cells , Pilot Projects , Proteinuria , Public Health , Renal Insufficiency, Chronic , Stem CellsABSTRACT
El actual SIMCE-EF (Sistema de Medición de la Calidad de la Educación Física), evalúa componentes de la condición física, que poco tienen que ver con los objetivos de la disciplina. El objetivo es determinar la influencia percibida por los docentes a sus prácticas educativas y en el entorno escolar, atribuida a la aplicación de la prueba SIMCE-EF. Se encuestan y entrevistan a 17 profesores de EF, pertenecientes al 100% de los establecimientos de la Comuna de Viña del Mar, Chile, que se les aplicó el SIMCE-EF en los años, 2010, 2011 y 2012. Según los docentes, la prueba no tiene impacto en el ámbito escolar, lo que podría mantener los resultados en las aplicaciones futuras, mientras se evalúe solo la condición física y en un formato piloto.
O atual SIMCE-EF (Sistema de Medição da Qualidade da Educação Física) avalia componentes da condição física que pouco têm a ver com os objetivos da disciplina de Educação Física. O objetivo deste trabalho é determinar a influência atribuída à implementação do teste SIMCE-EF pelos professores nas suas práticas educativas e no ambiente escolar. Foram entrevistados 17 professores de Educação Física, pertencentes a 100% dos estabelecimentos do município de Viña del Mar (Chile), que lhes aplicou o SIMCE-EF nos anos de 2010, 2011 e 2012. Segundo os docentes, os resultados encontrados indicam que SIMCE-EF não apresentam impacto no âmbito escolar, o que poderia assegurar resultados em aplicações futuras, sempre que se avalie somente a condição física em formato de estudo piloto.
The current SIMCE-EF (Physical Education Quality Measurement System) measures elements of physical fitness that have little to do with the discipline learning goals. The aim of this study is to determine how SIMCE-PEs influence is perceived by teachers on their own teaching practices and the school environment. Seventeen PE teachers were interviewed a hundred percent of the public system personnel in Viña del Mar, where the exams were applied in 2010, 2011, and 2012. According to the teachers, the exam has no impact on the school and such results can remain in the future since SIMCE-PE only measures physical fitness and in a pilot format.